Effects of methylglyoxal on human cardiac fibroblast : Roles of 1 transient receptor potential ankyrin 1 ( TRPA 1 ) channels

Effects of methylglyoxal on human cardiac fibroblast: Roles of 1 transient receptor potential ankyrin 1 (TRPA1) channels 2 3 Gaku Oguri, Toshiaki Nakajima, Yumiko Yamamoto, Nami Takano, Tomofumi 4 Tanaka, Hironobu Kikuchi, Toshihiro Morita, Fumitaka Nakamura, Tatsuya 5 Yamasoba, Issei Komuro 6 7 1) Department of Cardiovascular Medicine, University of Tokyo, Tokyo 113-8655, 8 Japan 9 2) Department of Ischemic Circulatory Physiology, University of Tokyo, Tokyo 10 113-8655, Japan 11 3) Department of Otolaryngology, University of Tokyo, Tokyo 113-8655, Japan 12 4) Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan 13 14 Address Correspondence to: Toshiaki Nakajima, Ph.D., MD 15 Department of Ischemic Circulatory Physiology, University of Tokyo, 7-3-1 Hongo, 16 Bunkyo-ku, Tokyo, Japan. 17 18 Phone: +81 3 3815 5411; Fax: +81 3 3814 0021 19 e-mail address: [email protected] 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Articles in PresS. Am J Physiol Heart Circ Physiol (August 29, 2014). doi:10.1152/ajpheart.01021.2013